9Īn increased dose of any sedating substance will increase crash risk as will the absence of tolerance. The prescriber and pharmacist must warn patients of these effects. Anticonvulsants, antidepressants and antipsychotics can also have sedative effects with the potential to affect driving ability. For sedating drugs, particularly benzodiazepines and opioids, the risk of having a motor vehicle collision is increased in the first four weeks after starting treatment and especially when combined with alcohol.
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